Article
No important role for genetic variation in the Chibby gene in monogenic and complex obesity.
Molecular biology reports - 1 Jul 2013
Van Camp Jasmijn K, Zegers Doreen, Verhulst Stijn L, Van Hoorenbeeck Kim, Massa Guy, Verrijken An, Desager Kristine N, Van Gaal Luc F, Van Hul Wim, Beckers Sigri
Abstract excerpt
Chibby (CBY) has been identified as a potent proadipogenic factor required for adipocyte differentiation. It has been shown that CBY inhibits the canonical Wnt pathway, and therefore promotes the development of new fat cells. Our objective therefore is to investigate the contribution of rare and common genetic variation in CBY to the development of human obesity. A mutation analysis was performed on a total of...
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