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Article

Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.

Annual review of nutrition - 1 Jan 2013

Michels Alexander J, Hagen Tory M, Frei Balz

Abstract excerpt

New evidence for the regulation of vitamin C homeostasis has emerged from several studies of human genetic variation. Polymorphisms in the genes encoding sodium-dependent vitamin C transport proteins are strongly associated with plasma ascorbate levels and likely impact tissue cellular vitamin C status. Furthermore, genetic variants of proteins that suppress oxidative stress or detoxify oxidatively damaged...

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Identifiers

PMID: 23642198
DOI: 10.1146/annurev-nutr-071812-161246
PMCID: PMC4357493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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