Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants.

doi:10.3945/ajcn.2010.29438

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Article

Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants.

The American journal of clinical nutrition - 1 Aug 2010

Timpson Nicholas J, Forouhi Nita G, Brion Marie-Jo, Harbord Roger M, Cook Derek G, Johnson Paul, McConnachie Alex, Morris Richard W, Rodriguez Santiago, Luan Jian'an, Ebrahim Shah, Padmanabhan Sandosh, Watt Graham, Bruckdorfer K Richard, Wareham Nicholas J, Whincup Peter H, Chanock Steve, Sattar Naveed, Lawlor Debbie A, Davey Smith George

Abstract excerpt

BACKGROUND: L-ascorbic acid is an essential part of the human diet and has been associated with a wide range of chronic complex diseases, including cardiovascular outcomes. To date, there are no confirmed genetic correlates of circulating concentrations of L-ascorbic acid. OBJECTIVE: We aimed to confirm the existence of an association between common variation at the SLC23A1 gene locus and circulating...

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PMID: 20519558
DOI: 10.3945/ajcn.2010.29438
PMCID: PMC3605792

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