Article
Hypertension and genetic variation in endothelial-specific genes.
PloS one - 1 Jan 2013
Larsson Erik, Wahlstrand Björn, Hedblad Bo, Hedner Thomas, Kjeldsen Sverre E, Melander Olle, Lindahl Per
Abstract excerpt
Genome-wide association (GWA) studies usually detect common genetic variants with low-to-medium effect sizes. Many contributing variants are not revealed, since they fail to reach significance after strong correction for multiple comparisons. The WTCCC study for hypertension, for example, failed to identify genome-wide significant associations. We hypothesized that genetic variation in genes expressed...
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