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Article

P-glycoprotein-9 and macrocyclic lactone resistance status in selected strains of the ovine gastrointestinal nematode, Teladorsagia circumcincta.

International journal for parasitology. Drugs and drug resistance - 1 Apr 2018

Turnbull Frank, Jonsson Nicholas N, Kenyon Fiona, Skuce Philip J, Bisset Stewart A

Abstract excerpt

The Teladorsagia circumcincta P-glycoprotein-9 (Tci-pgp-9) gene has previously been implicated in multiple-anthelmintic resistance in this parasite. Here we further characterise genetic diversity in Tci-pgp-9 and its possible role in ivermectin (IVM) and multi-drug resistance using two UK field isolates of T. circumcincta, one susceptible to anthelmintics (MTci2) and the other resistant to most available...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29414109
DOI: 10.1016/j.ijpddr.2018.01.004
PMCID: PMC6114102

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