Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome.

doi:10.1158/1078-0432.CCR-08-3266

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Article

Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2009

Rossi Davide, Spina Valeria, Cerri Michaela, Rasi Silvia, Deambrogi Clara, De Paoli Lorenzo, Laurenti Luca, Maffei Rossana, Forconi Francesco, Bertoni Francesco, Zucca Emanuele, Agostinelli Claudio, Cabras Antonello, Lucioni Marco, Martini Maurizio, Magni Michele, Deaglio Silvia, Ladetto Marco, Nomdedeu Josep F, Besson Caroline, Ramponi Antonio, Canzonieri Vincenzo, Paulli Marco, Marasca Roberto, Larocca Luigi M, Carbone Antonino, Pileri Stefano A, Gattei Valter, Gaidano Gianluca

Abstract excerpt

PURPOSE: Few biological prognosticators are useful for prediction of Richter syndrome (RS), representing the transformation of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. Stereotyped B-cell receptors (BCR) may have prognostic effect in CLL progression. We tested the prognostic effect of stereotyped BCR for predicting RS transformation. EXPERIMENTAL DESIGN: The prevalence of stereotyped BCR was...

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PMID: 19509140
DOI: 10.1158/1078-0432.CCR-08-3266

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