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Article

Association between gene and miRNA expression profiles and stereotyped subset #4 B-cell receptor in chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Jan 2015

Maura Francesco, Cutrona Giovanna, Mosca Laura, Matis Serena, Lionetti Marta, Fabris Sonia, Agnelli Luca, Colombo Monica, Massucco Carlotta, Ferracin Manuela, Zagatti Barbara, Reverberi Daniele, Gentile Massimo, Recchia Anna Grazia, Bossio Sabrina, Rossi Davide, Gaidano Gianluca, Molica Stefano, Cortelezzi Agostino, Di Raimondo Francesco, Negrini Massimo, Tassone Pierfrancesco, Morabito Fortunato, Ferrarini Manlio, Neri Antonino

Abstract excerpt

In this study we investigated specific biological and clinical features associated with chronic lymphocytic leukemia (CLL) patients carrying stereotyped BCR subset #4 (IGHV4-34) among a prospective cohort of 462 CLL/MBL patients in early stage (Binet A). All subset #4 patients (n = 16) were characterized by the IGHV mutated gene configuration, and absence of unfavorable cytogenetic lesions, NOTCH1 or SF3B1...

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Share to B-Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complementarity Determining Regions

Share to Gene Expression Regulation, Leukemic

Share to Immunoglobulin Variable Region

Share to Receptor, Notch1

Share to Receptors, Antigen, B-Cell

Share to Ribonucleoprotein, U2 Small Nuclear

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Source

Identifiers

PMID: 25860243
DOI: 10.3109/10428194.2015.1028051

Genes

BCR
BCL2
FGFR1
NOTCH1
PDGFA
TFEC
WDFY4

Provenance

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