Article
Biliary tract cancer stem cells - translational options and challenges.
World journal of gastroenterology - 14 Apr 2017
Mayr Christian, Ocker Matthias, Ritter Markus, Pichler Martin, Neureiter Daniel, Kiesslich Tobias
Abstract excerpt
Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells - the cancer stem cells - possesses stem cell properties. Cancer stem cells have high clinical relevance due to their...
Topics
- Animals
- Antineoplastic Agents
- Biliary Tract Neoplasms
- Biomarkers, Tumor
- Cell Lineage
- Cell Movement
- Cell Proliferation
- Humans
- Neoplastic Stem Cells
- Phenotype
- Signal Transduction