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Article

Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs.

American journal of physiology. Endocrinology and metabolism - 1 Jul 2013

Tello Javier A, Kohout Trudy, Pineda Rafael, Maki Richard A, Scott Struthers R, Millar Robert P

Abstract excerpt

The human GnRH receptor (GNRHR1) has a specific set of properties with physiological and pharmacological influences not appropriately modeled in laboratory animals or cell-based systems. To address this deficiency, we have generated human GNRHR1 knock-in mice and described their reproductive phenotype. Measurement of pituitary GNRHR1 transcripts from homozygous human GNRHR1 knock-in (ki/ki) mice revealed a severe...

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Identifiers

PMID: 23632635
DOI: 10.1152/ajpendo.00624.2012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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