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Interactions among Quorum Sensing Inhibitors

23 Apr 2013

Abstract excerpt

Many pathogenic bacteria use quorum sensing (QS) systems to regulate the expression of virulence genes in a density-dependent manner. In one widespread QS paradigm the enzyme LuxI generates a small diffusible molecule of the acyl-homoserine lactone (AHL) family; high cell densities lead to high AHL levels; AHL binds the transcription factor LuxR, triggering it to activate gene expression at a virulence promoter....

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PMID: 23626795
DOI: 10.1371/journal.pone.0062254

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