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Article

Effect of pitavastatin in different SLCO1B1 backgrounds on repaglinide pharmacokinetics and pharmacodynamics in healthy Chinese males.

Pakistan journal of pharmaceutical sciences - 1 May 2013

Zhu Jie, Song Min, Tan Hong-Yi, Huang Li-Hua, Huang Zhi-Jun, Liu Chang, Fu Zhi-Min, Huang Yuan-Yuan, Tan Zhi-Rong, Chen Xiao-Ping, Yuan Hong, Yang Guo-Ping

Abstract excerpt

The effect of pitavastatin and SLCO1B1 genetic background on the pharmacokinetic and pharmacodynamic properties of repaglinide was investigated. In this randomized, placebo-controlled, crossover study, twelve healthy Chinese males were administered with pitavastatin 4 mg/d or the placebo for 5 d followed by repaglinide 4 mg given orally on d 5. Plasma repaglinide and glucose levels were measured by liquid...

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PMID: 23625433

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