Article
Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential.
Cancer - 15 Apr 1996
Konno H, Tanaka T, Kanai T, Maruyama K, Nakamura S, Baba S
Abstract excerpt
BACKGROUND: The summation of gene mutations increases the metastatic potential of colorectal cancer. The genetic characterization and hepatic metastatic potential of five xenotransplanted human colon carcinoma strains were investigated. Furthermore, the therapeutic effect of the angiogenesis inhibitor, TNP-470, was evaluated. METHODS: The correlation between gene mutation and rate of hepatic metastases of five...
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