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Analysis of genomic abnormalities in tumors: a review of available methods for Illumina two-color SNP genotyping and evaluation of performance.

Cancer genetics - 1 Apr 2013

Oros Kathleen Klein, Arcand Suzanna L, Bayani Jane, Squire Jeremy A, Mes-Masson Anne-Marie, Tonin Patricia N, Greenwood Celia M T

Abstract excerpt

Several methods have recently been proposed for identifying copy number alterations (CNAs) in genomic DNA from tumors, using the signals arising from two-color genotyping technologies. Although copy number estimation in normal tissue has been well studied, methods developed for normal tissue tend to perform poorly when applied to tumors, due to normal cell contamination, varying levels of ploidy, and genetic...

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PMID: 23623180
DOI: 10.1016/j.cancergen.2013.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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