Article
Next-generation sequencing of cancer consensus genes in lymphoma.
Leukemia & lymphoma - 1 Aug 2013
Hüllein Jennifer, Jethwa Alexander, Stolz Tatjana, Blume Carolin, Sellner Leopold, Sill Martin, Langer Christian, Jauch Anna, Paruzynski Anna, von Kalle Christof, Schmidt Manfred, Glimm Hanno, Zenz Thorsten
Abstract excerpt
Sensitive identification of mutations in genes related to the pathogenesis of cancer is a prerequisite for risk-stratified therapies. Next-generation sequencing (NGS) in lymphoma has revealed genetic heterogeneity which makes clinical translation challenging. We established a 454-based targeted resequencing platform for robust high-throughput sequencing from limited material of patients with lymphoma. Hotspot...
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