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Article

Cancer chromosomes going to POT1.

Nature genetics - 1 May 2013

Chang Sandy

Abstract excerpt

Alterations in the single-stranded telomere-binding protein POT1 have recently been identified in chronic lymphocytic leukemia. This discovery provides novel insights into how genomic instability induced by dysfunctional telomeres contributes to tumorigenesis.

Read the complete abstract on PubMed

Topics

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Share to POT1 gene
Share to Leukemia, Lymphocytic, Chronic, B-Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Telomere-Binding Proteins

Source

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Identifiers

PMID: 23619786
DOI: 10.1038/ng.2617
PMCID: PMC4040961

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23619786-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Cancer chromosomes going to POT1.PMID 23619786Read ↗

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia.Semantic proximity Read ↗

Role of POT1 in Human CancerSemantic proximity Read ↗

The enigma of excessively long telomeres in cancer: lessons learned from rare human POT1 variantsSemantic proximity Read ↗

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endSemantic proximity Read ↗

Clinical, genetic, and familial features of POT1 tumor predisposition syndrome.Semantic proximity Read ↗

Germline mutations in Protection of Telomeres 1 in two families with Hodgkin lymphomaSemantic proximity Read ↗

Structural and functional analysis of the human POT1-TPP1 telomeric complex.Semantic proximity Read ↗

Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.Semantic proximity Read ↗

POT1 mutations cause differential effects on telomere length leading to opposing disease phenotypes.Semantic proximity Read ↗

POT1 tumour predisposition: a broader spectrum of associated malignancies and proposal for additional screening program.Semantic proximity Read ↗

Human POT1 Facilitates Telomere Elongation by TelomeraseSemantic proximity Read ↗

Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood.Semantic proximity Read ↗

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