Article
Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study.
Environmental toxicology and pharmacology - 1 Jul 2013
Siddarth Manushi, Datta Sudip K, Ahmed Rafat S, Banerjee Basu D, Kalra Om P, Tripathi Ashok K
Abstract excerpt
CYP1A1 is an important xenobiotic metabolizing enzyme, present in liver and kidney. Expression of CYP1A1 enzyme increases manifold when kidney cells are exposed to nephrotoxins/chemicals leading to oxidative stress-induced cell damage. To study the association of CYP1A1 gene polymorphism in patients of chronic kidney disease with unknown etiology (CKDU), we recruited 334 CKDU patients and 334 age and sex matched...
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