Article
Genetic variation in ESR2 and estrogen receptor-beta expression in lung tumors.
Cancer epidemiology - 1 Aug 2013
Song Ji Young, Siegfried Jill M, Diergaarde Brenda, Land Stephanie R, Bowser Robert, Stabile Laura P, Dacic Sanja, Dhir Rajiv, Nukui Tomoko, Romkes Marjorie, Weissfeld Joel L
Abstract excerpt
OBJECTIVE: To investigate the association between inherited variation in the estrogen receptor beta (ERβ) gene (ESR2) and ERβ lung tumor expression, a phenotype that possibly affects survival differently in men and women. METHODS: We genotyped 135 lung cancer patients for 22 ESR2 single nucleotide polymorphisms (SNPs) and measured nuclear and cytoplasmic ERβ expression by immunohistochemistry (IHC) in their...
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