Article
Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women.
Carcinogenesis - 1 Oct 2010
Olivo-Marston Susan E, Mechanic Leah E, Mollerup Steen, Bowman Elise D, Remaley Alan T, Forman Michele R, Skaug Vidar, Zheng Yun-Ling, Haugen Aage, Harris Curtis C
Abstract excerpt
The role of tumor estrogen receptors (ERs) and serum estrogen in lung cancer is inconclusive. We investigated the hypothesis that ERs and functional single-nucleotide polymorphisms in the estrogen biosynthesis pathway are associated with poorer lung cancer survival. Lung cancer patients (n = 305) from a National Cancer Institute-Maryland (NCI-MD) case-case cohort in the Baltimore metropolitan area were used as a...
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