Article
Prognostic and therapeutic implications of aromatase expression in lung adenocarcinomas with EGFR mutations.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2014
Kohno Mikihiro, Okamoto Tatsuro, Suda Kenichi, Shimokawa Mototsugu, Kitahara Hirokazu, Shimamatsu Shinichiro, Konishi Hideyuki, Yoshida Tsukihisa, Takenoyama Mitsuhiro, Yano Tokujiro, Maehara Yoshihiko
Abstract excerpt
PURPOSE: Lung adenocarcinomas among never-smokers are more common in females than in males. This implies that gender-dependent hormones promote smoking unrelated lung adenocarcinoma. We therefore investigated mRNA expression of aromatase, an intrinsic estrogen synthetase, in lung adenocarcinoma and assessed its correlation to clinicopathologic factors, including EGFR mutations and postsurgical prognosis....
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