Article
The c-ring stoichiometry of ATP synthase is adapted to cell physiological requirements of alkaliphilic Bacillus pseudofirmus OF4.
Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013
Preiss Laura, Klyszejko Adriana L, Hicks David B, Liu Jun, Fackelmayer Oliver J, Yildiz Özkan, Krulwich Terry A, Meier Thomas
Abstract excerpt
The c-rings of ATP synthases consist of individual c-subunits, all of which harbor a conserved motif of repetitive glycine residues (GxGxGxG) important for tight transmembrane α-helix packing. The c-ring stoichiometry determines the number of ions transferred during enzyme operation and has a direct impact on the ion-to-ATP ratio, a cornerstone parameter of cell bioenergetics. In the extreme alkaliphile Bacillus...
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