Article
Progranulin mutations as risk factors for Alzheimer disease.
JAMA neurology - 1 Jun 2013
Perry David C, Lehmann Manja, Yokoyama Jennifer S, Karydas Anna, Lee Jason Jiyong, Coppola Giovanni, Grinberg Lea T, Geschwind Dan, Seeley William W, Miller Bruce L, Rosen Howard, Rabinovici Gil
Abstract excerpt
IMPORTANCE: Mutations in the progranulin gene are known to cause diverse clinical syndromes, all attributed to frontotemporal lobar degeneration. We describe 2 patients with progranulin gene mutations and evidence of Alzheimer disease (AD) pathology. We also conducted a literature review. OBSERVATIONS: This study focused on case reports of 2 unrelated patients with progranulin mutations at the University of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.