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Article

Loss of progranulin function in frontotemporal lobar degeneration.

Trends in genetics : TIG - 1 Apr 2008

Cruts Marc, Van Broeckhoven Christine

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) represents a collection of neurodegenerative diseases of frontal and temporal brain regions. It has long been associated with mutations in microtubule-associated protein tau (MAPT), and more recently with loss-of-function mutations in progranulin (PGRN). P...

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Source

Identifiers

PMID: 18328591
DOI: 10.1016/j.tig.2008.01.004

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18328591-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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