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Article

Alpha 1-antitrypsin activity is markedly decreased in Wegener's granulomatosis.

Rheumatology international - 1 Apr 2014

Mota Ali, Sahebghadam Lotfi Abbas, Jamshidi Ahmad-Reza, Najavand Saeed

Abstract excerpt

Alpha 1-antitrypsin (A1AT) is the most abundant proteinase inhibitor in plasma and the main inhibitor of Proteinase 3, the target antigen of antineutrophil cytoplasmic antibodies (ANCAs) that predominant in Wegeners' granulomatosis. Α1AT deficiency correlated with ANCA-associated vasculitis. This study explores the trypsin inhibitory capacity (TIC), specific activity, and phenotypic deficiency of Α1AT in...

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Identifiers

PMID: 23604680
DOI: 10.1007/s00296-013-2745-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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