Article
Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis.
PLoS biology - 1 Feb 2022
Joyce Luke R, Manzer Haider S, da C Mendonça Jéssica, Villarreal Ricardo, Nagao Prescilla E, Doran Kelly S, Palmer Kelli L, Guan Ziqiang
Abstract excerpt
Bacterial membrane lipids are critical for membrane bilayer formation, cell division, protein localization, stress responses, and pathogenesis. Despite their critical roles, membrane lipids have not been fully elucidated for many pathogens. Here, we report the discovery of a novel cationic glycolipid, lysyl-glucosyl-diacylglycerol (Lys-Glc-DAG), which is synthesized in high abundance by the bacterium...
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