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Article

TPH1 A218C polymorphism and temperament in major depression.

BMC psychiatry - 18 Apr 2013

Andre Kadri, Kampman Olli, Viikki Merja, Illi Ari, Setälä-Soikkeli Eija, Poutanen Outi, Mononen Nina, Leinonen Esa, Lehtimäki Terho

Abstract excerpt

BACKGROUND: In major depression, one of the candidate genes possibly affecting the risk and severity of symptoms has been found to be tryptophan hydroxylase (TPH1). Variation in treatment response to antidepressive agents according to TPH1 genotype has also been found in several studies. However, the relationship between temperament and TPH1 genotype in major depression is poorly understood, as only one study has...

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Identifiers

PMID: 23597148
DOI: 10.1186/1471-244X-13-118
PMCID: PMC3704284

Genes

TPH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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