Article
The determinants for the enzyme activity of human parvovirus B19 phospholipase A2 (PLA2) and its influence on cultured cells.
PloS one - 1 Jan 2013
Deng Xuefeng, Dong Yanming, Yi Qianhui, Huang Yu, Zhao Dan, Yang Yongbo, Tijssen Peter, Qiu Jianming, Liu Kaiyu, Li Yi
Abstract excerpt
Human parvovirus B19 (B19V) is the causative agent of erythema infectiosum in humans. B19 infection also causes severe disease manifestations, such as chronic anemia in immunocompromised patients, aplastic crisis in patients with a high turnover rate of red blood cells, and hydrops fetalis in pregnant women. Although a secreted phospholipase A2 (PLA2) motif has been identified in the unique region of the B19V...
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