Article
Biological and immunological relations among human parvovirus B19 genotypes 1 to 3.
Journal of virology - 1 Jul 2007
Ekman Anna, Hokynar Kati, Kakkola Laura, Kantola Kalle, Hedman Lea, Bondén Heidi, Gessner Matthias, Aberham Claudia, Norja Päivi, Miettinen Simo, Hedman Klaus, Söderlund-Venermo Maria
Abstract excerpt
The human parvovirus B19 is now divided into three genotypes: type 1 (prototype), type 2 (A6- and LaLi-like), and type 3 (V9-like). In overall DNA sequence, the three virus types differ by approximately 10%. The most striking DNA dissimilarity, of >20%, is observed within the p6 promoter region. Because of the scarcity of data on the biological activities and pathogenetic potentials of virus types 2 and 3, we...
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