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Article

Molecular interactions of ErbB1 (EGFR) and integrin- 1 in astrocytoma frozen sections predict clinical outcome and correlate with Akt-mediated in vitro radioresistance

17 Apr 2013

Abstract excerpt

INTRODUCTION: Treatment of astrocytoma is frequently hampered by radioresistance of the tumor. In addition to overexpression of ErbB1/EGFR, functional crosstalk between receptor tyrosine kinases and cell adhesion molecules may also contribute to therapy resistance. METHODS: Acceptor photobleaching FRET was implemented on frozen sections of clinical astrocytoma to check the role of ErbB1-integrin-β1 interaction....

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PMID: 23595626
DOI: 10.1093/neuonc/not046

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