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Article

The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos.

Disease models & mechanisms - 1 Jul 2013

Smith Francis, Hu Diane, Young Nathan M, Lainoff Alexis J, Jamniczky Heather A, Maltepe Emin, Hallgrimsson Benedikt, Marcucio Ralph S

Abstract excerpt

Craniofacial anomalies can arise from both genetic and environmental factors, including prenatal hypoxia. Recent clinical evidence correlates hypoxia to craniofacial malformations. However, the mechanisms by which hypoxia mediates these defects are not yet understood. We examined the cellular mechanisms underlying malformations induced by hypoxia using a chicken (Gallus gallus) embryo model. Eggs were incubated...

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Identifiers

PMID: 23592613
DOI: 10.1242/dmm.011064
PMCID: PMC3701211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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