Article
Newly diagnosed adult AML and MPAL patients frequently show clonal residual hematopoiesis.
Leukemia - 1 Nov 2013
Fernandez C, Santos-Silva M C, López A, Matarraz S, Jara-Acevedo M, Ciudad J, Gutierrez M L, Sánchez M L, Salvador-Osuna C, Berruezo M J, Díaz-Arias J Á, Palomo-Hernández A M, Colado E, González N, Gallardo D, Asensio A, García-Sánchez R, Saldaña R, Cerveró C, Carboné-Bañeres A, Gutierrez O, Orfao A
Abstract excerpt
Adult acute myeloid leukemia (AML) is a highly heterogeneous stem cell malignancy characterized by the clonal expansion of immature myeloid precursors. AML may emerge de novo, following other hematopoietic malignancies or after cytotoxic therapy for other disorders. Here, we investigated the clonal vs reactive nature of residual maturing bone marrow cells in 59 newly diagnosed adult AML and mixed phenotype acute...
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