Article
Human leukocyte antigen class II alleles (DQB1 and DRB1) as predictors for response to interferon therapy in HCV genotype 4.
Mediators of inflammation - 1 Jan 2013
Shaker Olfat, Bassiony Heba, El Raziky Maissa, El-Kamary Samer S, Esmat Gamal, El-Ghor Akmal M, Mohamed Mona M
Abstract excerpt
Human leukocyte antigens class II play an important role in immune response against HCV. We investigated whether HLA class II alleles influence susceptibility to HCV infection and response to interferon therapy. HLA-DRB1 and -DQB1 loci were genotyped using PCR-SSO Luminex technology. According to our regimen, 41 (66%) of patients achieved sustained virological response to combined treatment of IFN and ribavirin....
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