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Functional assays to evaluate antibody-mediated responses against Shigella: a review

16 May 2023

Abstract excerpt

Shigella is a major global pathogen and the etiological agent of shigellosis, a diarrheal disease that primarily affects low- and middle-income countries. Shigellosis is characterized by a complex, multistep pathogenesis during which bacteria use multiple invasion proteins to manipulate and invade the intestinal epithelium. Antibodies, especially against the O-antigen and some invasion proteins, play a protective...

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PMID: 37260708
DOI: 10.3389/fcimb.2023.1171213

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