Article
No association of functional variant in pri-miR-218 and risk of congenital heart disease in a Chinese population.
Gene - 10 Jul 2013
Gao Xiaobo, Yang Liping, Ma Yan, Yang Juhua, Zhang Guican, Huang Guoying, Huang Qiuyu, Chen Liangwan, Fu Fangmeng, Chen Yandan, Su Dongmei, Dong Yi, Ma Xu, Lu Cailing, Peng Xiaozhong
Abstract excerpt
BACKGROUND: MiR-218 plays an important role in heart development in zebrafish. pri-miR-218 rs11134527 variant is associated with cervical cancer carcinogenesis. Therefore, we hypothesized that single nucleotide polymorphism (SNPs) in pri-miR-218 might influence susceptibility to sporadic congenital heart disease (CHD). METHODS AND RESULTS: We conducted a case-control study of CHD in a Chinese population to test...
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