Article
Genetic variants in the NOTCH4 gene influence the clinical features of migraine.
The journal of headache and pain - 26 Mar 2013
Rubino Elisa, Fenoglio Pierpaola, Gallone Salvatore, Govone Flora, Vacca Alessandro, De Martino Paola, Giobbe Maria Laura, Boschi Silvia, Pinessi Lorenzo, Gentile Salvatore, Rainero Innocenzo
Abstract excerpt
BACKGROUND: Recent studies suggested an important role for vascular factors in migraine etiopathogenesis. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The aim of this study was to test the hypothesis that polymorphisms of the NOTCH4 gene would modify the occurrence and the clinical features of migraine. FINDINGS: Using a case-control...
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