Article
Toll like receptor-4 896A/G gene variation, a risk factor for migraine headaches.
Iranian journal of immunology : IJI - 1 Sept 2012
Rafiei Alireza, Abedini Mahmoud, Hosseini Seyed Hamzeh, Hosseini-Khah Zahra, Bazrafshan Behrouz, Tehrani Mohsen
Abstract excerpt
BACKGROUND: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation. OBJECTIVE: This case/control study is aimed to investigate whether TLR-4 896A/G variation is related to migraine headaches in an Iranian population. METHODS: A...
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