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Article

NOTCH4 gene polymorphisms as potential risk factors for brain arteriovenous malformation development and hemorrhagic presentation.

Journal of neurosurgery - 1 May 2017

Delev Daniel, Pavlova Anna, Grote Alexander, Boström Azize, Höllig Anke, Schramm Johannes, Fimmers Rolf, Oldenburg Johannes, Simon Matthias

Abstract excerpt

OBJECTIVE Arteriovenous malformations (AVMs) of the brain are a frequent and important cause of intracranial hemorrhage in young adults. Little is known about the molecular-genetic pathomechanisms underlying AVM development. Genes of the NOTCH family control the normal development of vessels and proper arteriovenous specification. Transgenic mice with constitutive expression of active NOTCH4 frequently develop...

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Source

Identifiers

PMID: 27231971
DOI: 10.3171/2016.3.JNS151731

Genes

NOTCH4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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