Article
Thrombospondin-1 receptor mediates autophagy of RAS-expressing cancer cells and triggers tumour growth inhibition.
Anticancer research - 1 Apr 2013
Kalas Wojciech, Swiderek Ewelina, Switalska Marta, Wietrzyk Joanna, Rak Janusz, Strzadala Leon
Abstract excerpt
BACKGROUND: The anti-angiogenic activity of thrombospondin-1 (TSP-1) is suppressed in cancer cells, fact which has generated considerable interest in generating the respective therapeutic mimetics. These efforts were almost exclusively centered on peptides targeting CD36, the known TSP-1 receptor. Since the effects of these agents were less dramatic than those of full-length. TSP-1 questions could be raised about...
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