Article
Relationships between clinicopathological features and cerebrospinal fluid biomarkers in Japanese patients with genetic prion diseases.
PloS one - 1 Jan 2013
Higuma Maya, Sanjo Nobuo, Satoh Katsuya, Shiga Yusei, Sakai Kenji, Nozaki Ichiro, Hamaguchi Tsuyoshi, Nakamura Yosikazu, Kitamoto Tetsuyuki, Shirabe Susumu, Murayama Shigeo, Yamada Masahito, Tateishi Jun, Mizusawa Hidehiro
Abstract excerpt
A national system for surveillance of prion diseases (PrDs) was established in Japan in April 1999. Here, we analyzed the relationships among prion protein gene (PRNP) mutations and the clinical features, cerebrospinal fluid (CSF) markers, and pathological characteristics of the major genotypes of genetic PrDs (gPrDs). We retrospectively analyzed age at onset and disease duration; the concentrations and...
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