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Article

NSUN2 Promotes Cancer Immune Evasion via Its Moonlighting Function Acting on Metabolic Reprogramming.

Cancer communications (London, England) - 1 Jan 2026

Chen Baoxiang, Deng Yanrong, Zhai Xiang, Wang Peiyun, Lei Kunming, Yin Siyuan, Chen Quanjiao, Qian Qun, Zhang Jinfang, Ren Xianghai, Zhao Jianhong, Jiang Congqing

Abstract excerpt

Background: Although cancer immunotherapies have revolutionized cancer treatment, a substantial proportion of patients remain unresponsive. Elucidating the molecular mechanisms underlying tumor immune evasion and identifying key regulators are essential for improving immunotherapy efficacy. NOP2/Sun RNA methyltransferase 2 (NSUN2) exhibits widespread mutations across pan-cancer cohorts. This study aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42620795
DOI: 10.34133/cancomm.0042
PMCID: PMC13486727

Genes

NSUN2
GATA3
NOP2
SUCLG1
SUCLG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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