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Article

SH2B1 is Involved in the Accumulation of Amyloid-β42 in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Shen Yijun, Xia Yiling, Meng Shiquan, Lim Nastasia K H, Wang Wenan, Huang Fude

Abstract excerpt

Alzheimer's disease (AD) is characterized by deficits in learning and memory abilities, as well as pathological changes of amyloid-β (Aβ) plaque and neurofibrillary tangle formation in the brain. Insulin has been identified as a modulator of the neuronal pathways involved in learning and memory, and is also implicated as a modulator of Aβ and tau metabolism. Disrupted insulin signaling pathways are evident in AD...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27802221
DOI: 10.3233/JAD-160233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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