Article
Effect of long-term laboratory propagation on Chlamydia trachomatis genome dynamics.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2013
Borges Vítor, Ferreira Rita, Nunes Alexandra, Sousa-Uva Mafalda, Abreu Miguel, Borrego Maria J, Gomes João P
Abstract excerpt
It is assumed that bacterial strains maintained in the laboratory for long time shape their genome in a different fashion from the nature-circulating strains. Here, we analyzed the impact of long-term in vitro propagation on the genome of the obligate intracellular pathogen Chlamydia trachomatis. We fully-sequenced the genome of a historical prototype strain (L2/434/Bu) and a clinical isolate (E/CS88), before and...
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