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Article

Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors.

PloS one - 1 Jan 2015

Borges Vítor, Pinheiro Miguel, Antelo Minia, Sampaio Daniel A, Vieira Luís, Ferreira Rita, Nunes Alexandra, Almeida Filipe, Mota Luís J, Borrego Maria J, Gomes João P

Abstract excerpt

Research on the obligate intracellular bacterium Chlamydia trachomatis demands culture in cell-lines, but the adaptive process behind the in vivo to in vitro transition is not understood. We assessed the genomic and transcriptomic dynamics underlying C. trachomatis in vitro adaptation of strains...

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Identifiers

PMID: 26207372
DOI: 10.1371/journal.pone.0133420
PMCID: PMC4514472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26207372-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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