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Article

Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors.

PloS one - 1 Jan 2015

Borges Vítor, Pinheiro Miguel, Antelo Minia, Sampaio Daniel A, Vieira Luís, Ferreira Rita, Nunes Alexandra, Almeida Filipe, Mota Luís J, Borrego Maria J, Gomes João P

Abstract excerpt

Research on the obligate intracellular bacterium Chlamydia trachomatis demands culture in cell-lines, but the adaptive process behind the in vivo to in vitro transition is not understood. We assessed the genomic and transcriptomic dynamics underlying C. trachomatis in vitro adaptation of strains representing the three disease groups (ocular, epithelial-genital and lymphogranuloma venereum) propagated in...

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Identifiers

PMID: 26207372
DOI: 10.1371/journal.pone.0133420
PMCID: PMC4514472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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