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Article

Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors.

BMC cancer - 20 Mar 2012

Ghosh Gargi, Lian Xiaojun, Kron Stephen J, Palecek Sean P

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) signaling plays an important role in non-small cell lung cancer (NSCLC) and therapeutics targeted against EGFR have been effective in treating a subset of patients bearing somatic EFGR mutations. However, the cancer eventually progresses during treatment with EGFR inhibitors, even in the patients who respond to these drugs initially. Recent studies have...

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Share to Antigens, CD
Share to Cell Survival
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erlotinib Hydrochloride

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Source

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Identifiers

PMID: 22433462
DOI: 10.1186/1471-2407-12-95
PMCID: PMC3364915

Genes

EGFR
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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