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Article

Regulation of the MDR1 promoter by E2F1 and EAPP

28 Mar 2013

Abstract excerpt

Multidrug resistance (MDR), one of the main reasons for diminishing efficacy of prolonged chemotherapy, is frequently caused by the elevated expression of the ABCB1/MDR1 gene encoding PGP (P-glycoprotein). EAPP (E2F Associated PhosphoProtein) is a frequently overexpressed protein in human tumor cells. It inhibits apoptosis in a p21-dependent manner. We show here that EAPP stimulates the MDR1 promoter resulting in...

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PMID: 23542036
DOI: 10.1016/j.febslet.2013.03.026

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