Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells

5 Apr 2008

Abstract excerpt

The development of multidrug resistance 1 (MDR1) can be mediated by a number of different mechanisms but elevated gene expression of MDR1 (P-glycoprotein) has often been a major cause of chemoresistance in many cancer cells. Therefore, the present study aimed to investigate the role of forkhead box-containing protein, O subfamily (FoxO), transcription factors in regulating the MDR1 gene expression. The proximal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to FOXO transcription factor regulation
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18390843
DOI: 10.1093/carcin/bgn092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cellsPMID 18390843Read ↗

SIRT1-Mediated FoxO1 Deacetylation Is Essential for Multidrug Resistance-Associated Protein 2 Expression in Tamoxifen-Resistant Breast Cancer CellsSemantic proximity Read ↗

Role and regulation of FOXO3a: new insights into breast cancer therapySemantic proximity Read ↗

Role of FoxO Proteins in Cellular Response to Antitumor AgentsSemantic proximity Read ↗

FOXO transcription factors in cancer development and therapy.Semantic proximity Read ↗

A New Fork for Clinical Application: Targeting Forkhead Transcription Factors in CancerSemantic proximity Read ↗

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistanceSemantic proximity Read ↗

Deciphering the roles of FOXO1 in human neoplasmsSemantic proximity Read ↗

FOXO Signaling Pathways as Therapeutic Targets in CancerSemantic proximity Read ↗

Role of FOXO Transcription Factors in Cancer Metabolism and AngiogenesisSemantic proximity Read ↗

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistanceSemantic proximity Read ↗

Therapeutic strategies targeting FOXO transcription factorsSemantic proximity Read ↗

CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.