Article
Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1.
Biomaterials - 1 Jun 2013
Mentink Anouk, Hulsman Marc, Groen Nathalie, Licht Ruud, Dechering Koen J, van der Stok Johan, Alves Hugo A, Dhert Wouter J, van Someren Eugene P, Reinders Marcel J T, van Blitterswijk Clemens A, de Boer Jan
Abstract excerpt
Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To this end, we isolated hMSCs from 62 donors and characterized systematically their in vitro lineage differentiation...
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