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Article

Potency Biomarker Signature Genes from Multiparametric Osteogenesis Assays: Will cGMP Human Bone Marrow Mesenchymal Stromal Cells Make Bone?

PloS one - 1 Jan 2016

Murgia Alba, Veronesi Elena, Candini Olivia, Caselli Anna, D'souza Naomi, Rasini Valeria, Giorgini Andrea, Catani Fabio, Iughetti Lorenzo, Dominici Massimo, Burns Jorge S

Abstract excerpt

In skeletal regeneration approaches using human bone marrow derived mesenchymal stromal cells (hBM-MSC), functional evaluation before implantation has traditionally used biomarkers identified using fetal bovine serum-based osteogenic induction media and time courses of at least two weeks. However, emerging pre-clinical evidence indicates donor-dependent discrepancies between these ex vivo measurements and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27711115
DOI: 10.1371/journal.pone.0163629
PMCID: PMC5053614

Genes

MSC
ALPL
DCN
ELN
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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