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Article

Molecular evolution of the hepatitis B virus genome.

Journal of molecular evolution - 1 Nov 1995

Yang Z, Lauder I J, Lin H J

Abstract excerpt

The hepatitis B virus (HBV) has a circular DNA genome of about 3,200 base pairs. Economical use of the genome with overlapping reading frames may have led to severe constraints on nucleotide substitutions along the genome and to highly variable rates of substitution among nucleotide sites. Nucleotide sequences from 13 complete HBV genomes were compared to examine such variability of substitution rates among sites...

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PMID: 7490773
DOI: 10.1007/BF00175817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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