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Article

Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase.

Journal of biomolecular structure & dynamics - 1 Jan 2014

Wuxiuer Yimingjiang, Winberg Jan-Olof, Sylte Ingebrigt

Abstract excerpt

Enzyme kinetics studies have shown that Scaptodrosophila lebanonensis alcohol dehydrogenase (SlADH) and other drosophilid alcohol dehydrogenases function by a compulsory-ordered mechanism where the coenzyme binds to the free enzyme, and that a proton is released upon formation of the binary enzyme-NAD(+) complex. A proton relay mechanism for the proton abstraction has been suggested that includes an...

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PMID: 23528031
DOI: 10.1080/07391102.2013.776502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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