Article
Induction of RET dependent and independent pro-inflammatory programs in human peripheral blood mononuclear cells from Hirschsprung patients.
PloS one - 1 Jan 2013
Rusmini Marta, Griseri Paola, Lantieri Francesca, Matera Ivana, Hudspeth Kelly L, Roberto Alessandra, Mikulak Joanna, Avanzini Stefano, Rossi Valentina, Mattioli Girolamo, Jasonni Vincenzo, Ravazzolo Roberto, Pavan William J, Pini-Prato Alessio, Ceccherini Isabella, Mavilio Domenico
Abstract excerpt
Hirschsprung disease (HSCR) is a rare congenital anomaly characterized by the absence of enteric ganglia in the distal intestinal tract. While classified as a multigenic disorder, the altered function of the RET tyrosine kinase receptor is responsible for the majority of the pathogenesis of HSCR. Recent evidence demonstrate a strong association between RET and the homeostasis of immune system. Here, we utilize a...
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